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Estrone Explained: How Lifestyle & Hormones Impact Women’s Health
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In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, dives deep into estrone, one of the three key estrogens, and explains why understanding it is crucial for women’s health. Learn about: The differences between estradiol, estriol, and estrone How estrone levels shift during perimenopause and menopause Why oral estrogen can dramatically increase estrone The impact of lifestyle factors like diet, body fat, stress, alcohol, and sedentary behavior on estrogen balance Practical tips to support healthy estrogen metabolism naturally Dr. McCarthy breaks down complex biochemistry in a clear, actionable way so you can take charge of your hormonal health. Citations: 1. Bulun, Serdar E., et al. “Aromatase and Estrogen Biosynthesis in Adipose Tissue.” Endocrine Reviews, vol. 23, no. 3, 2002, pp. 305–342. 2. Labrie, Fernand, et al. “Importance of the Intracrinology of Estrogen Synthesis in Peripheral Tissues in Postmenopausal Women.” Journal of Steroid Biochemistry and Molecular Biology, vol. 118, nos. 4–5, 2010, pp. 273–279. 3. Sasano, Hironobu, and Toshihiko Harada. “Differential Expression of Aromatase and 17β-Hydroxysteroid Dehydrogenase Isoenzymes in Human Tissues.” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3–5, 2003, pp. 327–333. 4. Yager, James D., and Nancy E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine, vol. 354, no. 3, 2006, pp. 270–282. 5. Cavalieri, Ercole L., and Eleanor G. Rogan. “Depurinating Estrogen-DNA Adducts, Mechanisms of Formation, and Prevention.” Clinical Cancer Research, vol. 16, no. 3, 2010, pp. 596–602. 6. Suba, Zsuzsanna. “Circulating Estrogens and Estrogen Metabolism in Obese Women.” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 11, 2013, pp. 4336–4344. 7. Simpson, Evan R., and Konstanze C. Pike. “Aromatase Expression in Adipose Tissue: Relationship to Obesity and Insulin Resistance.” Endocrinology, vol. 156, no. 9, 2015, pp. 3422–34
This content is for education and is not medical advice. It does not replace an evaluation with a licensed provider, and no one should start, stop or change a medication on its basis.
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