Podcast

Vaginal Estrogen, Menopause & Hormones: What Your Doctor May Not Be Telling You

Podcast · 23 min · Aug 19, 2026 · Dr. Brendan McCarthy

About this episode

Vaginal and urinary symptoms are common during perimenopause and menopause—but understanding why they happen and how different forms of estrogen work can be confusing. In Episode 8 of this hormone series, Dr. Brendan McCarthy breaks down the relationship between systemic estrogen, vaginal estrogen, estradiol, estriol, testosterone, and the genitourinary symptoms many women experience during menopause. He discusses: Why oral estrogen doesn't necessarily reach every tissue in the body the way you might expect The difference between systemic and vaginal estrogen Why vaginal estrogen can be an important medical intervention—not simply a "cream" How estrogen can affect vaginal tissue, pH, and urinary health The role of androgens like testosterone in vaginal and genitourinary health What we know—and still don't know—about vaginal estrogen transfer to a partner Why informed consent means truly understanding your treatment Questions you can ask your provider about your hormone therapy and monitoring Dr. McCarthy's goal is simple: to give women unbiased information so they can feel more informed, curious, and confident when making decisions about their health. This episode is for educational purposes only and is not a substitute for individualized medical advice. Talk with your healthcare provider about what treatment approach is appropriate for you.

This content is for education and is not medical advice. It does not replace an evaluation with a licensed provider, and no one should start, stop or change a medication on its basis.

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