Sulfation, Trauma, and Why Progesterone Doesn’t Always Calm You

About this episode

In this episode of the podcast, Dr. Brendan McCarthy—Chief Medical Officer of Protea Medical Center in Tempe, Arizona—continues his in-depth progesterone series with a deep dive into reverse responders and an often-overlooked mechanism: hormone sulfation. Many women take progesterone expecting better sleep, calmer moods, and reduced anxiety—yet feel more alert, only mildly calmer, or see no benefit at all. This episode explains why that doesn’t mean progesterone is wrong for you. Dr. McCarthy breaks down: What progesterone reverse responding really is The difference between 5-alpha reductase pathways and sulfation How the brain uses sulfation to buffer stress and trauma Why progesterone may be stored instead of calming the nervous system The role of chronic stress, PTSD, perimenopause, and hormone volatility Why higher doses can make things worse How thoughtful, low-dose, individualized hormone therapy actually works Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you’re ready to take your health seriously, this podcast is a great place to start. 👇 Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.